醫師介紹
醫師學術論文
Paper
張雅琁 Ya-Sian Chang 副研究員
張雅琁從事基因研究多年,建立了許多的臨床檢驗方法,並將研究成果發表於國際期刊上;目前研究以次世代基因體定序在臨床應用為主,包含癌症和遺傳病,希望將自己所學應用在臨床上。
相關連結
學術機構典藏
論文
期刊論文
期刊論文/Journal Paper (作者群,論文題目,期刊名稱,出版年月,卷號(期別):頁次起迄) |
日期 | |
1 | (Eskezeia Yihunie Dessie)、塗翔鈞(TU SIANG-JYUN)、姜惠珊(Hui-Shan Chiang)、(Jeffrey J.P. Tsai)、張雅琁(Ya-Sian Chang)*、張建國(Jan-Gowth Chang)*、(Ka-Lok Ng)*,Construction and Validation of a Prognostic Gene-Based Model for Overall Survival Prediction in Hepatocellular Carcinoma Using an Integrated Statistical and Bioinformatic Approach,INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2021 Feb,22():1632 | 2021 . 02 |
2 | 張雅琁(Ya-Sian Chang)、塗翔鈞(TU SIANG-JYUN)、陳郁佳(Yu-Chia Chen)、劉鼎元(Ting-Yuan Liu)、李雅婷(Ya-Ting Lee)、顏汝珍(Ju-Chen Yen)、方信元(Hsin-Yuan Fang)、張建國(Jan-Gowth Chang)*,Mutation profile of non-small cell lung cancer revealed by next generation sequencing,RESPIRATORY RESEARCH,2021 Jan,22():3 | 2021 . 01 |
3 | 張雅琁(Ya-Sian Chang)、塗翔鈞(TU SIANG-JYUN)、姜惠珊(Hui-Shan Chiang)、顏汝珍(Ju-Chen Yen)、李雅婷(Ya-Ting Lee)、方信元(Hsin-Yuan Fang)、張建國(Jan-Gowth Chang)*,Genome-wide analysis of prognostic alternative splicing signature and splicing factors in lung adenocarcinoma,Genes,2020 Oct,11():E1300 | 2020 . 10 |
4 | 張雅琁(Ya-Sian Chang)、蕭麗雲(Li-Yun Hsiao)、林建佑(Chien-Yu Lin)、施木青(Mu-Chin Shih)、謝明家*、張建國(Jan-Gowth Chang)*,Fasting glucose-to-HbA1c ratio is a good indicator of G6PD deficiency, but not thalassemia, in patients with type 2 diabetes mellitus.,CLINICA CHIMICA ACTA,2020 Mar,506():9-15 | 2020 . 03 |
5 | (Pei?Chin Lin)、(Chao-Neng Cheng)、(Hsi-Yuan Huang)、(Yu-Hsin Tseng)、張雅琁(Ya-Sian Chang)、林建佑(Chien-Yu Lin)、張建國(Jan-Gowth Chang)*,Congenital dyserythropoiesis anemia type Ia with a novel CDAN1 mutation diagnosed by whole exome sequencing.,Molecular Genetics & Genomic Medicine,2020 Mar,():e1220 | 2020 . 03 |
6 | 郭煌宗(Haung-Tsung Kuo)、陳傑賀(Chen, Chieh Ho)、(Chien-Yu Lin)、張雅琁(Ya-Sian Chang)*、張建國(Jan-Gowth Chang)*,Chromosomal microarray analysis in Taiwanese patients with Williams-Beuren syndrome,CYTOGENETIC AND GENOME RESEARCH,2020 Jan,/():/-/ | 2020 . 01 |
7 | 張雅琁(Ya-Sian Chang)、張傑閔(Chieh-Min Chang)、(Chien-Yu Lin)、趙代勝(Dy-San Chao)、(Hsi-Yuan Huang)、張建國(Jan-Gowth Chang)*,Pathway mutations in breast cancer using whole-exome sequencing,ONCOLOGY RESEARCH,2019 Oct,/(): | 2019 . 10 |
8 | 張雅琁(Ya-Sian Chang)、(Chien-Yu Lin)、(Hsi-Yuan Huang)、張建國(Jan-Gowth Chang)*、郭煌宗(Haung-Tsung Kuo)*,Chromosomal microarray and whole-exome sequence analysis in Taiwanese patients with autism spectrum disorder,Molecular Genetics & Genomic Medicine,2019 Oct,/(/):/-/ | 2019 . 10 |
9 | 李建志(Chien-Chin Lee)、(Wen-Hsin Chang)、張雅琁(Ya-Sian Chang)、(Jinn-Moon Yang)、張誌祥(Chih-Shiang Chang)、(Kai-Cheng Hsu)、(Yun-Ti Chen)、劉鼎元(Ting-Yuan Liu)、陳郁佳(Yu-Chia Chen)、(Shyr-Yi Lin)*、吳永昌(Yang-Chang Wu)*、張建國(Jan-Gowth Chang)*,Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxide,Molecular Oncology,2019 Aug,13(8):1744-1762 | 2019 . 08 |
10 | 賴羿如(Lai, I-Lu)、張雅琁(Ya-Sian Chang)、詹雯玲(Wen-Ling Chan)、李雅婷(Ya-Ting Lee)、顏汝珍(Ju-Chen Yen)、楊晶安(Chin-An Yang)、洪詩雅(Shih-Ya Hung)、張建國(Jan-Gowth Chang)*,Male-Specific Long Noncoding RNA TTTY15 Inhibits Non-Small Cell Lung Cancer Proliferation and Metastasis via TBX4,INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2019 Jul,20(14):3473 | 2019 . 07 |
11 | 張雅琁(Ya-Sian Chang)、(Chien?Chin Lee)、柯道維(Tao-Wei Ke)、張傑閔(Chieh-Min Chang)、趙代勝(Dy-San Chao)、(Hsi?Yuan Huang)、張建國(Jan-Gowth Chang)*,Molecular characterization of colorectal cancer using wholeexome sequencing in a Taiwanese population,Cancer Medicine,2019 May,/(/):/-/ | 2019 . 05 |
12 | (Pei-Chin Lin)、(Shyh-Shin Chiou)、(Chien-Yu Lin)、(Shu-Chen Wang)、黃熙淵(Hsi-Yuan Huang)、張雅琁(Ya-Sian Chang)、(Yu-Hsin Tseng)、(Tzu-Min Kan)、(Yu-Mei Liao)、(Shih-Pien Tsai)、彭慶添(Ching-Tien Peng)*、張建國(Jan-Gowth Chang)*,Whole-exome sequencing for the genetic diagnosis of congenital red blood cell membrane disorders in Taiwan.,CLINICA CHIMICA ACTA,2018 Dec,487():311-317 | 2018 . 12 |
13 | 張雅琁(Ya-Sian Chang)、方信元(Hsin-Yuan Fang)、洪耀欽(Yao-Ching Hung)、柯道維(Tao-Wei Ke)、張傑閔(Chieh-Min Chang)、劉鼎元(Ting-Yuan Liu)、陳郁佳(Yu-Chia Chen)、趙代勝(Dy-San Chao)、黃熙淵(Hsi-Yuan Huang)、張建國(Jan-Gowth Chang)*,Correlation of genomic alterations between tumor tissue and circulating tumor DNA by next-generation sequencing,JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,2018 Sep,/(/):1-9 | 2018 . 09 |
14 | 張雅琁(Ya-Sian Chang)、李建志(Lee Chien-Chih)、黃熙淵(Hsi-Yuan Huang)、林宏(Kuo-Hung Lin)、陳建佑(Jan-Yow Chen)、張坤正(Kuan-Cheng Chang)*、張建國(Jan-Gowth Chang)*,Detection of Variants in Patients with Idiopathic Ventricular Fibrillation by Whole-exome Sequencing,ANNALS OF CLINICAL AND LABORATORY SCIENCE,2018 Aug,48(): | 2018 . 08 |
15 | 張雅琁(Ya-Sian Chang)、(Chun-Chi Chang)、黃熙淵(Hsi-Yuan Huang)、(Chien-Yu Lin)、(Kun-Tu Yeh)、張建國(Jan-Gowth Chang)*,Detection of Molecular Alterations in Taiwanese Patients with Medullary Thyroid Cancer Using Whole-Exome Sequencing,ENDOCRINE PATHOLOGY,2018 Aug,/():1-8 | 2018 . 08 |
16 | 張竣期(Chun-Chi Chang)、劉鼎元(Ting-Yuan Liu)、李雅婷(Ya-Ting Lee)、陳郁佳(Yu-Chia Chen)、葉坤土(Kun-Tu Yeh)、李建志(Chien-Chih Lee)、(Ya-Ling Chen)、林佩瑾(Pei-Chin Lin)、張雅琁(Chang, Ya-Sian)*、詹雯玲(Wen-Ling Chan)*、劉大智(Ta-Chih Liu)*、張建國(Chang, Jan-Gowth)*,Genome-wide analysis of lncRNAs in 3'-untranslated regions: CR933609 acts as a decoy to protect the INO80D gene,INTERNATIONAL JOURNAL OF ONCOLOGY,2018 Jul,53(1):417-433 | 2018 . 07 |
17 | (Chun-Chi Chang)、張雅琁(Chang, Ya-Sian)、黃熙淵(Hsi-Yuan Huang)、(Kun-Tu Yeh)、(Ta-Chih Liu)*、張建國(Chang, Jan-Gowth)*,Determination of the mutational landscape in Taiwanese patients with papillary thyroid cancer by whole-exome sequencing,HUMAN PATHOLOGY,2018 May,78():151-158 | 2018 . 05 |
18 | 賴羿如、楊晶安(Yang, Chin-An)、(Pei-Chin Lin)、(Wen-Ling Chan)、李雅婷(Ya-Ting Lee)、顏汝珍(Ju-Chen Yen)、張雅琁(Chang, Ya-Sian)*、張建國(Chang, Jan-Gowth)*,Long noncoding RNA MIAT promotes non-small cell lung cancer proliferation and metastasis through MMP9 activation,Oncotarget,2017 Oct,10.18632/o(): | 2017 . 10 |
19 | 李建志(Chien-Chih Lee)、(Chang WH)、張雅琁(Chang, Ya-Sian)、劉鼎元(Ting-Yuan Liu)、陳郁佳(Yu-Chia Chen)、(Wu YC)*、張建國(Chang, Jan-Gowth)*,4β-Hydroxywithanolide E Modulates Alternative Splicing of Apoptotic Genes in Human Hepatocellular Carcinoma Huh-7 Cells,Scientific Reports,2017 Aug,7(1):7290 | 2017 . 08 |
20 | 張雅琁(Chang, Ya-Sian)、(Hsien-Da Huang)、(Kun-Tu Yeh)、張建國(Jan-Gowth Chang)*,Identification of novel mutations in endometrial cancer patients by whole-exome sequencing,INTERNATIONAL JOURNAL OF ONCOLOGY,2017 Mar,/():/-/ | 2017 . 03 |
21 | 劉鼎元(Ting-Yuan Liu)、陳郁佳(Yu-Chia Chen)、(Jong YJ)、(Tsai HJ)、李建志(Chien-Chih Lee)、張雅琁(Chang, Ya-Sian)、張建國(Chang, Jan-Gowth)*、(Chang YF)*,Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice,Open Biology,2017 Jan,7(1): | 2017 . 01 |
22 | 楊晶安(Chin-An Yang)、黃熙淵(Hsi-Yuan Huang)、張雅琁(Chang, Ya-Sian)、林佳麗、(I-Lu Lai)、張建國(Jan-Gowth Chang)*,DNA-Sensing and Nuclease Gene Expressions as Markers for Colorectal Cancer Progression,ONCOLOGY,2017 ,92(2):115-124 | 2017 . |
23 | 張雅琁(Chang, Ya-Sian)、(Hsien-Da Huang)、(Kun-Tu Yeh)、張建國(Jan-Gowth Chang)*,Evaluation of whole exome sequencing by targeted gene sequencing and Sanger sequencing,CLINICA CHIMICA ACTA,2017 ,471():222-232 | 2017 . |
24 | (Yuli C. Chang)、(Chien-Chih Chiu)、(Chung-Yee Yuo)、(Wen-Ling Chan)、張雅琁(Chang, Ya-Sian)、(Wen-Hsin Chang)、(Shou-Mei Wu)、(Han-Lin Chou)、(Ta-Chih Liu)、(Chi-Yu Lu)、(Wen-Kuang Yang)、張建國(Jan-Gowth Chang)*,An XIST-related small RNA regulates KRAS G-quadruplex formation beyond X-inactivation,Oncotarget,2016 Dec,7(52):86713-86729 | 2016 . 12 |
25 | 林佩瑾(Pei-Chin Lin)、黃憲達(Hsien-Da Huang)、張竣期(Chun-Chi Chang)、張雅琁(Chang, Ya-Sian)、顏汝珍(Ju-Chen Yen)、李建志(Chien-Chih Lee)、張文馨(Wen-Hsin Chang)、劉大智(Ta-Chih Liu)*、張建國(Jan-Gowth Chang)*,Long noncoding RNA TUG1 is downregulated in non-small cell lung cancer and can regulate CELF1 on binding to PRC2,BMC CANCER,2016 Aug,10(1186):s12885-016-2569-6 | 2016 . 08 |
26 | 廖顯鋒、李建志(Chien-Chih Lee)、(Pei-Chi Hsiao)、(Yi-Fong Chen)、(Chih-Hua Tseng)、(Cherng-Chyi Tzeng)、(Yeh-Long Chen)、(Jui-Chang Chen)、張雅琁(Chang, Ya-Sian)*、張建國(Jan-Gowth Chang)*,TCH1036, a indeno[1,2-c]quinoline derivative, potentially inhibited the growth of human brain malignant glioma (GBM) 8401 cells via suppression of the expression of Suv39h1 and PARP,BIOMEDICINE & PHARMACOTHERAPY,2016 Aug,10(1016):j.biopha-2016.06002 | 2016 . 08 |
27 | 廖顯鋒、李賢雄(Hsien-Hsiung Lee)、張雅琁(Chang, Ya-Sian)、林佳麗、劉鼎元(Ting-Yuan Liu)、陳郁佳、顏汝珍(Ju-Chen Yen)、李雅婷(Ya-Ting Lee)、林建佑(Chien-Yu Lin)、吳世雄(Shih-Hsiung Wu)、葛應欽(Ying-Chin Ko)*、張建國(Jan-Gowth Chang)*,Down-regulated and Commonly mutated ALPK1 in Lung and Colorectal Cancers,Scientific Reports,2016 Jul,10(1038):/srep27350 | 2016 . 07 |
28 | (Yuli Christine Chang)、張雅琁(Chang, Ya-Sian)、(Chun-Chi Chang)、(Ta-Chih Liu)、葛應欽(Ying-Chin Ko)、李建志(Chien-Chih Lee)、(Shun-Jen Chang)、張建國(Jan-Gowth Chang)*,Development of a high-resolution melting method for the screening TNFAIP3 gene mutations,ONCOLOGY REPORTS,2016 Mar,35():2936-2942 | 2016 . 03 |
29 | 張雅琁(Chang, Ya-Sian)、林建佑(Chien-Yu Lin)、楊淑芬(Shu-Fen Yang)、何承懋(Cheng-Mao Ho)、張建國(Jan-Gowth Chang)*,Analysing the mutational status of adenomatous polyposis coli (APC) gene in breast cancer,Cancer Cell International,2016 Mar,16(23):1-6 | 2016 . 03 |
30 | 張雅琁、林建佑(Chien-Yu Lin)、(Shu-Fen Yang)、何承懋(Cheng-Mao Ho)、張建國(Jan-Gowth Chang)*,High resolution melting analysis for gene scanning of adenomatous polyposis coli (APC) gene with oral squamous cell carcinoma samples,APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY,2016 Feb,24(2):97-104 | 2016 . 02 |
31 | (Yuli Christine Chang)、張建國(Jan-Gowth Chang)、(Ta-Chih Liu)、林建佑(Chien-Yu Lin)、楊淑芬(Shu-Fen Yang)、何承懋(Cheng-Mao Ho)、陳自諒(William Tzu-Liang Chen)、張雅琁(Chang, Ya-Sian)*,Mutation analysis of 13 driver genes of colorectal cancer-related pathways in Taiwanese patients,WORLD JOURNAL OF GASTROENTEROLOGY,2016 Feb,22(7):2314-2325 | 2016 . 02 |
32 | 張雅琁(Chang, Ya-Sian)、(Hsien-Da Huang)、(Kun-Tu Yeh)、張建國(Jan-Gowth Chang)*,Genetic alterations in endometrial cancer by targeted next-generation sequencing,EXPERIMENTAL AND MOLECULAR PATHOLOGY,2016 Jan,100():8-12 | 2016 . 01 |
33 | 陳尚文(Shang-Wen Chen)、林建佑(Chien-Yu Lin)、何承懋(Cheng-Mao Ho)、張雅琁(Chang, Ya-Sian)、楊淑芬(Shu-Fen Yang)、高嘉鴻(Chia-Hung Kao)*、張建國(Jan-Gowth Chang),Genetic Alterations in Colorectal Cancer Have Different Patterns on 18F-FDG PET/CT.,CLINICAL NUCLEAR MEDICINE,2015 Aug,40(8):621-626 | 2015 . 08 |
34 | 張雅琁、楊逸紋、林晏年(Yen-Nien Lin)、林?宏(Kuo-Hung Lin)、張坤正(Kuan-Cheng Chang)*、張建國(Jan-Gowth Chang)*,Mutation analysis of KCNQ1, KCNH2 and SCN5A genes in Taiwan long QT syndrome patients,International Heart Journal,2015 Jun,(): | 2015 . 06 |
35 | 盧秀琴(Hsiu-Chin Lu)、張雅琁、(Chun-Chi Chang)、(Ching-Hsiung Lin)、張建國(Jan-Gowth Chang)*,Developing and evaluating the HRM technique for identifying cytochrome P450 2D6 polymorphisms,JOURNAL OF CLINICAL LABORATORY ANALYSIS,2015 May,(): | 2015 . 05 |
36 | (Chun-Chi Chang)、張雅琁、(Wen-Ling Chan)、(Kun-Tu Yeh)、(Ren-Jeng Wei)、張建國(Jan-Gowth Chang)*,Detection of SF3B3 gene mutations in oral cancer by high resolution melting analysis,Clinical Laboratory,2014 Dec,60(0):2023-2029 | 2014 . 12 |
37 | 張雅琁、李建志(Chien-Chih Lee)、(Ting-Yuan Liu)、(Yu-Chia Chen)、盧秀琴(Hsiu-Chin Lu)、張建國(Jan-Gowth Chang)*,Direct assessment of cytochrome P450 2D6 genotypes by high-resolution melting analysis and DNA sequencing,ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2014 Sep,38(0):821-828 | 2014 . 09 |
38 | 張雅琁、(Hui-Ting Hsu)、葛應欽(Ying-Chin Ko)、(Kun-Tu Yeh)、(Shun-Jen Chang)、林建佑(Chien-Yu Lin)、張建國(Jan-Gowth Chang)*,Combined mutational analysis of RAS, BRAF, PIK3CA, and TP53 genes in Taiwanese patients with oral squamous cell carcinoma,Oral Surgery Oral Medicine Oral Pathology Oral Radiology,2014 Jul,118(1):110-116 | 2014 . 07 |
39 | 張雅琁、(Tze-Kiong Er)、盧秀琴(Hsiu-Chin Lu)、(Kun-Tu Yeh)、張建國(Jan-Gowth Chang)*,Detection of KRAS codon 12 and 13 mutations by mutant-enriched PCR assay,CLINICA CHIMICA ACTA,2014 May,436(2014):169-175 | 2014 . 05 |
40 | 張雅琁、(Chang SJ)、(Yeh KT)、林彩秀(Tsai-Hsiu Lin)、張建國(Jan-Gowth Chang)*,RAS, BRAF, and TP53 gene mutations in taiwanese colorectal cancer patients.,ONKOLOGIE,2013 Nov,36(12):719-724 | 2013 . 11 |
41 | 張雅琁、(I-Ling Lin)、(Kun-Tu Yeh)、張建國(Jan-Gowth Chang)*,Rapid detection of K-, N-, H-RAS, and BRAF hotspot mutations in thyroid cancer using the multiplex primer extension.,CLINICAL BIOCHEMISTRY,2013 Oct,46(15):1572-1577 | 2013 . 10 |
研討會論文
研討會論文/Conference Papers (發表主題或論文名稱,研討會名稱,演講地點,研討會期間,受邀演講題目) |
日期 | |
1 | 整合性RNA-seq自動分析平台於口腔癌研究,The Thirteenth Chinese Laboratory Medicine Conference - Precision and Integration in Laboratory Medicine,City University of Hong Kong,2017.11.17~2017.11.20, | 2017 . 11 |
專書
暫無資料研究計畫
研究計畫/Research Grant (研究類型,研究計畫代號,主持人,補助或委託單位名稱,計畫名稱,計畫期間) |
日期 | |
1 | 個別型,DMR-107-100,張建國(Chang, Jan-Gowth),附醫院內計畫,探討甲狀腺癌的代謝及相關的治療方法,2017.8.1~2018.7.31 | 2017 . 08 |
2 | 非研究型計畫 (例如:課程計畫),MOST 105-2811-B-039-038,黃憲達、張永福、張雅琁(Chang, Ya-Sian),科技部,探討srpk 2基因剔除小鼠的行為異常及致癌機轉,2016.8.1~2017.7.31 | 2016 . 08 |
3 | 個別型,MOST 103-2320-B-039 -050-MY3,黃憲達、張永福、張雅琁(Chang, Ya-Sian),科技部,探討srpk 2基因剔除小鼠的行為異常及致癌機轉,2016.8.1~2017.7.31 | 2016 . 08 |
4 | 個別型,DMR-106-105,張建國(Jan-Gowth Chang),附醫院內計畫,利用次世代定序技術建立液體切片常見癌症相關基因的分子檢驗方法,以大腸直腸癌為例,2016.8.1~2017.7.31 | 2016 . 08 |
5 | 個別型,MOST 103-2320-B-039 -050-MY3,黃憲達、張永福、張雅琁(Chang, Ya-Sian),科技部,探討srpk 2基因剔除小鼠的行為異常及致癌機轉,2015.8.1~2016.7.31 | 2015 . 08 |
6 | 非研究型計畫 (例如:課程計畫),MOST 104-2811-B-039-011,黃憲達、張永福、張雅琁(Chang, Ya-Sian),科技部,探討srpk 2基因剔除小鼠的行為異常及致癌機轉,2015.8.1~2016.7.31 | 2015 . 08 |
7 | 非研究型計畫 (例如:課程計畫),MOST 103-2811-B-039-030,黃憲達、張永福、張雅琁(Chang, Ya-Sian),科技部,探討srpk 2基因剔除小鼠的行為異常及致癌機轉,2014.8.2~2015.7.31 | 2014 . 08 |
8 | 個別型,MOST 103-2320-B-039 -050-MY3,黃憲達、張永福、張雅琁,科技部,探討srpk 2基因剔除小鼠的行為異常及致癌機轉,2014.8.1~2015.7.31 | 2014 . 08 |