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A 53-year-old man suffered from palpitations, chest tightness, and decreased physical stamina for two years. After medical evaluation, he was diagnosed with severe mitral valve prolapse with regurgitation and critical stenosis of the coronary artery—facing a dual threat to his heart. Fortunately, he successfully underwent Taiwan’s first combined NeoChord (beating-heart artificial chordae repair) and PCI (percutaneous coronary intervention) procedure.