• Product Name: Paxlovid
• Content: Nirmatrelvir 150 mg 2 tablets and Ritonavir 100 mg 1 tablet
• Medicine Shape:
• Nirmatrelvir 150 mg tablet, oval, pink film-coated tablets, printed with PFE on one side and 3CL on the other side.
• Ritonavir 100 mg tablet, white film-coated tablet, printed with H on one side and R9 on the other side.
• Applicant: To be prescribed to adult patients and children patients (aged at least 12 years and weigh at least 40 KG) with mild-to-moderate COVID-19 at high risk of severe disease, and have onset within 5 days.

Administration and Dosage

• Paxlovid comprises of 2 medicines, namely Nirmatrelvir and Ritonavir. Take oral dosage twice a day (morning and evening). Each dosage requires two pink tablets and 1 white tablet. Take 3 tablets at the same time and for 5 days.
• Take the medicine with or without meal. Take the whole tablet. Do not chew, separate or crush the tablet. Do not alter the dosage or suspend medication without the authorization under doctor instructions.
• If the dosage is not taken within the routine 8 hours, please take the medicine as soon as possible. If you forget to take the medicine after 8 hours, please omit the medication and start with next dosage. Do not double the dosage.
• Patients with poor renal function shall follow physician instruction and requirement for reduction of medication.

Morning Medication	Evening Medication

Advantage/Disadvantage of Treatment

• Clinical investigation suggests that taking the preceding oral antiviral medicine could help shorten the course of disease, alleviate disease severity and lower mortality rate. However, the effect of medicine is not 100% effective and it is possible that you could experience worsening symptoms or new symptoms from the treatment.

Storage Instruction

• Please store the medicine with the medicine bag in an airtight container under room temperature and dry place. Avoid sunlight. It is recommended to store in the blister package and only take the medicine as needed. Avoid storage in a place accessible to children.

Possible Adverse Reaction

• Poor appetite, yellow skin or eyes (jaundice), dark urine, light stool color,skin itch, and stomach (abdomen) ache.
• Other possible side effect: change of taste (bitter), diarrhea, elevated blood pressure, and muscular ache.

Precautions

• If you are taking the medicine containing ritonavir or cobicistat for treatment of Hepatitis C or human immunodeficiency virus (HIV), follow the instruction and continue the treatment.
• Do not take the medicine if you are allergic to any substance in Paxlovid.
• This medicine may interact with many other medications. Please inform your healthcare team about all medicines you are taking. Consult your physician or pharmacist before starting any new medication.

Other Precautions

• To ensure treatment effectiveness, do not stop the medication even if your symptoms improve.
• Clinical experience with Paxlovid is limited. Serious or unexpected adverse reactions may occur. If you experience any unusual, persistent, or worsening symptoms, please contact your physician or pharmacist.
• Website for original pharmaceutical company: www.COVID19oralRx.com