MabThera®SC is a combination of rituximab and hyaluronidase. Rituximab is a monoclonal antibody that targets to a protein called CD20 on the surface of white blood cells known as B lymphocytes. When rituximab attaches to these cells, the abnormal growth of the B lymphocytes is stopped and triggers cell death. Hyaluronidase is added to increase absorption of rituximab under the skin.
Temsirolimus is a kinase inhibitor which inhibits the mTOR kinase. The mTOR kinase is responsible for cell growth and proliferation. By blocking this kinase, temsirolimus can slow the growth of cancer cells.
Topotecan is a synthetic analogue of camptothecin, a nature product derived from the Camptotheca acuminata, also called the happy tree. Topotecan blocks the action of an enzyme in cells called topoisomerase I, which is necessary for cell replication and tumor growth. Blocking this enzyme leads to breaks in the DNA, which leads to cancer cell death.
Trastuzumab is a monoclonal antibody which targets the human epidermal growth factor receptor 2 (HER2) on cells. HER2 is found in large amounts on the surface of some cancer cells, resulting in tumors growing more quickly. By attaching to the HER2, trastuzumab blocks HER2 from receiving growth signals, preventing further cancer growth and slowing cancer progression.
Herceptin®SC is a combination of trastuzumab and hyaluronidase. Trastuzumab is a monoclonal antibody which targets the human epidermal growth factor receptor 2 (HER2) on cells. HER2 is found in large amounts on the surface of some cancer cells, resulting in tumors growing more quickly.
Ankylosing spondylitis (AS) is a chronic and systemic inflammatory disease, which needs close attention to prevent comorbidity.
Rheumatoid arthritis (RA) is a chronic and progressive inflammatory joint disease that can affect all of peripheral joints.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that cannot be cured by medicine or food, but can be controlled steadily with medications as well as good care.
When patients with lupus erythematosus have active disease activity, they often feel tired and fatigued, mainly due to the inflammatory process in the body and the release of inflammatory related substances, which causes the patients to feel tired.
The conventional medications used for rheumatoid arthritis include nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and disease-modifying anti-rheumatic drugs (DMARDs).