Besponsa® is an antibody-drug conjugate combining a cytotoxic agent called calicheamicin with a monoclonal antibody, which targets a protein called CD22 on the surface of B cells.
Ipilimumab is a monoclonal antibody that binds to CTLA-4 (human cytotoxic T lymphocyte-associated antigen 4) on T cells. By blocking CTLA-4, ipilimumab helps strengthen the immune system by promoting the function and growth of T cells, thereby enhancing the immune system against cancer cells.
Trastuzumab is a monoclonal antibody which targets the human epidermal growth factor receptor 2 (HER2) on cells. HER2 is found in large amounts on the surface of breast cancer cells, resulting in tumors growing more quickly. By attaching to the HER2 receptor, trastuzumab blocks HER2 from receiving growth signals, preventing further cancer growth and slowing cancer progression.
Melphalan is an alkylating agent that exerts its anticancer activity by reacting with DNA and interfering with DNA replication and cell division. This stops the growth and spread of cancer cell in the body.
Nivolumab is a monoclonal antibody that binds to PD-1 (Programmed cell death protein 1) and blocks its interaction with PD-L1 (programmed cell death ligand 1).
Obinutuzumab is a monoclonal antibody that targets to a protein called CD20 on the surface of white blood cells known as B lymphocytes. When obinutuzumab attaches to the surface of these cells, the abnormal growth of the B lymphocytes is stopped.
Olaratumab is a monoclonal antibody that binds to platelet-derived growth factor receptor-alpha (PDGFRα), which locates on the surface of cancer cells. This drug blocks the activation of PDGFRα, thus inhibiting cell proliferation and tumor growth.
Onivyde® is irinotecan covered in tiny spheres called liposomes. These spheres keep irinotecan in the bloodstream longer and help irinotecan get through the dense stroma of the pancreatic tumor, thus significantly enhancing the efficacy of irinotecan in tumor tissue.
Paclitaxel is a plant alkaloid derived from the bark of the Pacific Yew tree. Paclitaxel inhibits the action of proteins called microtubules for cell division, thus stopping cancer cells from separating into two new cells, eventually causing cell death.
Panitumumab is a monoclonal antibody which targets the epidermal growth factor receptor (EGFR) on cells. EGFR is found in large amounts on the surface of some cancer cells, resulting in tumors growing more quickly.