衛教資訊
Causes of Type 1 and Type 2 Diabetes 1型和2型糖尿病發病原因
Causes of Type 1 and Type 2 Diabetes 1型和2型糖尿病發病原因
Type 1 Diabetes
The cause is insulin deficiency, which may be related to viral infection and the autoimmune mechanism. We can infer that after viral infection, pancreatic islet β cells are damaged, and β cells are reduced. Due to an autoimmune disorder, antibodies against β cells are increased, and then pancreatic islet secretion function is impaired and even suffers serious damage, thus causing the onset of diabetes.
Some patients with type 1 diabetes have autoimmune diseases and immune antibodies in various organs. The disease occurs when β cells are damaged by lymphocytic infiltration of the pancreatic islets. More pathogenic factors such as genetic problems and β cell apoptosis are still being studied.
Type 2 Diabetes
The pathogenesis mainly lies in the relative lack of insulin secretion, the high insulin resistance, the imbalance of insulin supply and demand, and the inability to properly deal with the rise of blood sugar, which has already existed in pre-diabetes. The incidence of type 2 diabetes mellitus is closely related to the following factors:
- Insulin resistance occurs in body tissues, especially insulin-dependent tissues such as adipocytes, muscles and liver.
- The secretion of first phase insulin after food intake for islet cytokines is impaired, which increases post-meal blood sugar.
- Abnormal increase of hepatic gluconeogenesis.
- The existence of non-immune insulin antagonism impedes insulin action in blood circulation.
- The chemical properties of insulin molecules are changed by the internal environment, which lowers the effective effect of insulin, that is, the biological activity of insulin molecules caused by isomerism is reduced.
- American Diabetes Association.
- The Diabetes Association of the Republic of China (Taiwan) (2022). DAROC Clinical Practice Guidelines for Type 2 Diabetes Care- 2022. The Diabetes Association of the Republic of China (Taiwan).
- The Diabetes Association of the Republic of China (Taiwan) (2022). DAROC Clinical Practice Guidelines for Type 1 Diabetes Care- 2022. The Diabetes Association of the Republic of China (Taiwan).
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