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English Brand Name & Chinese Name
Imfinzi^®; 抑癌寧注射劑

Drug Introduction
Durvalumab is a PD-L1 immune checkpoint inhibitor and a monoclonal antibody. It works by enhancing the body’s own immune system to increase its ability to fight tumors, thereby achieving a therapeutic effect. Clinically, it can be used alone or in combination with other drugs to treat non-small cell lung cancer, small cell lung cancer, biliary tract cancer, and hepatocellular carcinoma.

How It Is Administered
Administered as an intravenous infusion over at least 1 hour. The treatment interval and number of doses are determined by the physician based on clinical judgment.

Precautions Before and During Administration

• Before starting treatment, inform your doctor if you have any of the following conditions:
  • Autoimmune disease
  • History of organ transplant
  • Respiratory or lung disease
  • Liver disease
  • Kidney disease
  • Diabetes
  • Thyroid disease
• Avoid using medications that may affect immune function, including vaccines, during treatment. If you need such medications or vaccinations, consult your doctor first.
• Avoid pregnancy or breastfeeding during treatment. If pregnancy is suspected, notify your doctor immediately.
• Durvalumab may affect fetal development. Women should use effective contraception during treatment and for at least 3 months after the last dose.
• Durvalumab may cause high blood sugar. If you have diabetes, inform your doctor before starting therapy and monitor blood sugar closely during treatment.

Possible Side Effects

• Allergic reactions: If itching, rash, swelling of the face or hands, swelling or tingling of the lips or throat, chest tightness, difficulty breathing, dizziness, or palpitations occur during infusion, notify healthcare personnel immediately.
• Common adverse reactions: Fever, cough, diarrhea, abdominal pain, skin itching, rash, joint pain.
• Other immune-related adverse reactions:
  • Immune-mediated colitis
  • Immune-mediated hepatitis
  • Immune-mediated pneumonitis
  • Immune-mediated dermatitis
  • Immune-mediated neuropathy
  • Immune-mediated endocrinopathies

If you experience symptoms such as pneumonitis (abnormal cough, productive cough, shortness of breath), hepatitis (jaundice, severe nausea/vomiting, or right-sided abdominal pain), nephritis (decreased urine output, blood in urine, swelling in the lower limbs), or endocrinopathies (high blood sugar, hyperthyroidism, or hypothyroidism), seek medical attention immediately.

Dietary Considerations

• Inform your doctor if you are taking any over-the-counter medicines, herbal products, or vitamin supplements.
• Avoid raw or undercooked food, as well as expired or spoiled food, during treatment to reduce the risk of infection due to lowered immunity.
• If you have special dietary needs or questions, you may book a nutrition consultation for personalized advice from a dietitian.